Ramon Garcia-Escudero,  PhD

I am a molecular and translational oncology researcher with extensive experience in cancer biology and a long-standing interest in oral potentially malignant disorders (OPMDs), head and neck squamous cell carcinoma (HNSCC), and Fanconi anemia-associated malignancies.

Research focus

My research focuses on the molecular mechanisms that drive oral carcinogenesis, tumour progression and therapeutic response. I am particularly interested in how premalignant lesions progress to invasive cancer, how tumour cells adapt to biological and therapeutic pressures, and how these processes can reveal clinically relevant biomarkers and therapeutic vulnerabilities.

Approach

Our group combines disease-relevant preclinical models, molecular biology, multi-omic approaches and biomarker research. We have developed and work with experimental models of OPMDs and HNSCC, including models specifically designed to study Fanconi anemia-associated oral cancer.

These platforms allow us to:

- investigate cancer initiation and progression
- evaluate therapeutic strategies
- identify molecular vulnerabilities
- explore biomarkers for early detection, patient stratification and treatment response

Translational goal

My broader goal is to help translate molecular and preclinical discoveries into new strategies for cancer prevention, early detection, patient stratification and safer, more effective treatment.

Current affiliations

I currently conduct my research at CIEMAT, where I lead the Head and Neck Cancer Unit within the Biomedical Innovation Department. I am also affiliated with the imas12 Research Institute at Hospital Universitario 12 de Octubre. I am a member of CIBERONC, part of the Instituto de Salud Carlos III network in Spain.